A Northwestern Medicine study published in Molecular Psychiatry has uncovered how the antipsychotic drug haloperidol can cause side effects resembling Parkinson's disease. Researchers found that inhibiting LRRK2, a protein linked to dopamine receptor signaling, lessened haloperidol's harmful motor side effects in mice. These findings open the door for developing new treatment strategies combining haloperidol with small-molecule kinase inhibitors, aimed at making treatment safer for individuals suffering from psychosis and related disorders.
Inhibiting LRRK2 both pharmacologically and genetically in mice reduced haloperidol's side effects, suggesting potential strategies to mitigate its harmful impacts on motor function.
The study elucidates the molecular mechanisms behind haloperidol-induced side effects, potentially leading to safer treatment options for psychosis and related disorders.
#antipsychotic-medication #parkinsons-disease-symptoms #lrrk2-inhibition #haloperidol #neurological-disorders
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