The article discusses intratumoural heterogeneity in childhood medulloblastoma, particularly in groups 3 and 4, which complicates effective treatment and results in low survival rates. Recent advancements in DNA methylation and single-cell transcriptomic profiling have classified these tumours into eight distinct molecular subgroups, revealing the complex interactions of transcription factors and signalling pathways that foster cellular diversity. Despite identifying single-gene oncogenic drivers, the overarching role of genetic events in medulloblastoma initiation and evolution remains unresolved. The study uses advanced profiling methods to explore driver oncogenic events and their roles in tumour dynamics.
Intratumoural heterogeneity complicates effective treatment of medulloblastoma, which is defined by diverse molecular populations, particularly in groups 3 and 4.
Recent advancements have enabled us to categorize heterogeneous group 3/4 medulloblastoma tumours into eight distinct subgroups, revealing intricate cellular diversity.
Collection
[
|
...
]