"Clade I cases in Central and Eastern African countries at first spread through heterosexual intimate or sexual contact between adults, then spread likely occurred within households, including to children."
"As of late 2025, central Western European countries began reporting clade I mpox cases among individuals who had no documented history of international travel, likely related to intimate or sexual exposure among men who have sex with men."
"The mpox virus spreads through close - usually skin-to-skin - contact with someone who is infected, including direct contact with infectious rashes or scabs."
"Symptoms of clade I and clade II mpox are similar, often starting as flu-like conditions, and the virus appears as a rash or sores resembling pimples or blisters."
Clade I mpox cases initially spread through heterosexual contact in Central and Eastern Africa, later affecting households. By late 2025, cases in Western Europe emerged among individuals without travel history, likely linked to intimate contact among men who have sex with men. The CDC anticipates more cases in Europe and the U.S. Mpox spreads through close contact with infected individuals, including skin-to-skin contact and exposure to bodily fluids. Symptoms include flu-like conditions and a painful rash that can appear anywhere on the body.
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