"There are also clear downsides to the diet. Ketones are acidic, and if they build up too much in the blood, they can be toxic, causing ketoacidosis. This is a particular concern for people with type 1 diabetes and for people with chronic alcohol abuse. For everyone else, there's a list of common side effects, including nausea, vomiting, constipation, diarrhea, bad breath, headache, fatigue, and dizziness. Ketogenic diets are also linked to high cholesterol and kidney stones."
"The rash was first identified in Japan in 1971, where it was mostly seen in women. While it has been consistently linked to metabolic disorders and dietary changes, experts still don't understand what causes it. It's seen not only in people on a keto diet but also in people with diabetes and those who have had bariatric surgery or are fasting."
The ketogenic diet often leads to rapid weight loss and anecdotal improvements in stamina and mental clarity, but strong clinical evidence is limited and long-term cardiovascular risks remain a concern. Ketones are acidic and excessive blood ketone levels can cause toxic ketoacidosis, especially in type 1 diabetes and chronic alcohol abuse. Common side effects include nausea, vomiting, constipation, diarrhea, bad breath, headache, fatigue, and dizziness, and ketogenic diets are associated with elevated cholesterol and kidney stones. A poorly understood inflammatory skin condition called prurigo pigmentosa (keto rash) causes red, itchy bumps and hyperpigmentation and is linked to metabolic changes; a leading hypothesis implicates neutrophil-driven perivascular inflammation from high ketone levels.
Read at Ars Technica
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