"The man had nasal polyps and used sinus rinses to alleviate his symptoms. However, his symptoms didn't start in his nasal passages-they started on his legs."
"Doctors worried that his immune system was attacking his blood vessels, causing the necrotic lesions. So, they put him on immunosuppressant drugs. But his condition only worsened."
"The Yale doctors noted that the lesions began after he returned from Florida, where he spent the winters. While there, he was exposed to a red tide."
"They then sought and got approval from the Food and Drug Administration for a single-patient experimental trial of an antibiotic (nitroxoline) that had shown success in treating a different amoeba."
A man developed Acanthamoeba infection after using sinus rinses for nasal polyps. His symptoms began with red nodules on his legs, progressing to necrotic lesions. Initial tests showed inflammation but no bacterial or fungal pathogens. After worsening, he was transferred to Yale, where a biopsy revealed amoeba-like cells. DNA testing confirmed Acanthamoeba. Despite a five-drug regimen, his condition deteriorated, prompting an experimental antibiotic trial for treatment.
Read at Ars Technica
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