""Traditionally, scientists assumed that in epithelial cells, mRNAs are more or less evenly distributed in the cytosol. The idea was that proteins are made anywhere in the epithelial cell, and then the proteins go where they need to function. What we found challenges that dogma.""
""The new study shows that this organizational principle extends to protein synthesis itself. Some of the molecular machinery responsible for making proteins - ribosomes - are recruited by desmosomes and are localized near the outer membrane of the cell rather than evenly distributed throughout the interior.""
""Together, these findings define a previously unrecognized system of mRNA organization, suggesting that where an mRNA sits inside a cell can be just as important as what it encodes.""
A new study reveals that skin cells utilize a novel mechanism to organize protein production, crucial for homeostasis and wound healing. Researchers found that ribosomes and messenger RNAs cluster near the cell's outer membrane, challenging the traditional view of protein synthesis in epithelial cells. This study highlights the importance of mRNA localization in addition to its genetic coding role. The research also uncovers a new function of desmoplakin, a protein integral to desmosomes, which are essential for cell adhesion in skin tissues.
Read at News Center
Unable to calculate read time
Collection
[
|
...
]