"Ozempic and all of these gut hormones have their primary effect through the back of the brain. The hypothalamus is the hunger sensor. It operates from dealing with starvation to no starvation. It's trying to detect within your body. Am I starving or not? How hungry am I?"
"The problem with targeting here is that the side effects are then nausea. In other words, the big reason why the side effects are prevalent is due to the hindbrain's focus on fullness, which can lead to uncomfortable sensations."
A new generation of weight-loss treatments, including BRP, offers effective obesity management with fewer side effects. Current drugs like Ozempic and Wegovy suppress appetite but can cause nausea and other gastrointestinal issues. BRP, discovered at Stanford Medicine, primarily acts on the hypothalamus, the brain region responsible for hunger regulation. Unlike existing treatments that target the hindbrain and induce feelings of fullness, BRP aims to control appetite without the discomfort of nausea, potentially providing a safer alternative for weight loss.
Read at www.dw.com
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