"Researchers observed that T cells behaved differently in blood samples collected from ALS patients than they did in samples from donors without the disease. And, while those with a mutated gene that affects C9orf72 expression in neurons did have stronger effects, the balance of inflammatory and anti-inflammatory chemicals was affected to some extent in all ALS patients, regardless of whether they had the mutation or not."
"C9orf72, a protein present in brain cells that has long been suspected of playing a role in the disease. Genetic mutations detected in roughly 10% to 15% of all patients who develop the condition affect the expression of this protein, causing much speculation that altered versions of this molecule may cause damage to motor neurons, causing patients to gradually lose control of their muscles and eventually their ability to breathe."
T cells in blood samples from amyotrophic lateral sclerosis patients behave differently than in donors without the disease, altering the balance of inflammatory and anti-inflammatory chemicals in the brain. The presence of C9orf72 in brain cells influences T-cell behavior, and genetic mutations that affect C9orf72 expression occur in roughly 10–15 percent of patients, producing stronger immune effects. Motor neuron damage from altered molecules can lead to progressive muscle control loss and eventual respiratory failure. The inflammatory imbalance appears in patients with and without the C9orf72 mutation, implying broader immune system involvement. These findings point to autoimmune mechanisms and open potential new treatment directions and explanations for variable patient survival.
Read at www.sandiegouniontribune.com
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