"In the study, the scientists analyzed data from 21,241 participants in UK Biobank. The UK Biobank data also includes detailed imaging of the heart and blood vessels. Artificial intelligence was used to analyse these images to capture signs of organ aging -- such as tissues becoming stiff and inflamed. An individual was given a "heart age" which can be compared to their actual age at the time of the scan."
"The scientists leading the research say that visceral body fat could play an important role in accelerating aging of the heart and blood vessels. This type of fat is known to be harmful to health and this study now links it to faster heart aging. The study, led by scientists from the Medical Research Council (MRC) Laboratory of Medical Sciences, in London, UK, also found differences between men and women, and discovered that fat around the hips and thighs could potentially slow heart aging in women."
Visceral fat surrounding internal organs is associated with accelerated cardiac aging, manifested by myocardial stiffening and inflammation. Whole-body and cardiac MRI from 21,241 UK Biobank participants were analysed with artificial intelligence to quantify regional fat depots and derive a "heart age" compared to chronological age. Greater visceral adipose tissue correlated with older heart age, whereas subcutaneous fat around hips and thighs correlated with slower heart aging in women, indicating sex-specific effects of fat distribution. Imaging-derived organ-aging biomarkers link regional adiposity to cardiovascular deterioration and potential differential metabolic protection from peripheral subcutaneous fat.
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