This article highlights the crucial role of conventional dendritic cells (DCs) in initiating and maintaining cancer immunity. It documents a progressive decline in migratory DCs in tumor-draining lymph nodes during cancer progression, impairing T cell priming. Through a genome-wide CRISPR screen, the research identified phosphodiesterase 5 (PDE5) and cGMP as significant regulators of DC migration. The findings suggest that pharmacological inhibition of PDE5 can restore DC migratory abilities, potentially enhancing antitumor immune responses.
The study shows that conventional dendritic cells (DCs) are critical for T cell responses against tumors, underscoring the need for effective DC migration to lymph nodes.
A genome-wide CRISPR screen revealed that phosphodiesterase 5 (PDE5) and cyclic guanosine monophosphate (cGMP) are essential for regulating DC migration during tumor progression.
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