For some people, music doesn't connect with any of the brain's reward circuits
Briefly

A neuroscientist and colleagues spent ten years investigating specific musical anhedonia, a condition in which individuals derive no pleasure from music. Pleasure normally arises from interactions between sensory perception circuits and reward circuits that release dopamine. Hearing impairments prevent correct perception of music; global reward-circuit dysfunction prevents enjoyment across all stimuli. Clinical cases show intact auditory perception and normal pleasure from other rewards, such as winning money, while music alone fails to elicit enjoyment. Those cases point to a selective disruption in communication between auditory-processing regions and reward pathways as the likely mechanism underlying the condition.
I was talking with my colleagues at a conference 10 years ago and I just casually said that everyone loves music,
When your reward circuit doesn't work, you don't experience enjoyment from anything, not just music,
But some people have no hearing impairments and can enjoy everything else-winning money, for example. The only thing they can't enjoy is music.
Read at Ars Technica
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