"Sep 29, 2025, 03:06 PM ET NFL's Week 5 slate gets underway with a matchup of NFC West rivals when the San Francisco 49ers visit the Los Angeles Rams on "Thursday Night Football." Sunday night features another division rivalry when the Buffalo Bills host the New England Patriots. The week wraps up with the Kansas City Chiefs hitting the road to take on the Jacksonville Jaguars on "Monday Night Football" (8:15 p.m. ET on ABC/ESPN)."
"San Francisco 49ers vs. Los Angeles Rams -4.5 Thursday, 8:15 p.m., Prime Video Money Line: 49ers (+190); Rams (-225) Total: 47.5; Opened: 46.5 FPI favorite: Rams by 2.6 with a 57.2% probability to win the game outright Minnesota Vikings -3.5 vs. Cleveland Browns Sunday, 9:30 a.m., NFL Net, NFL+ Money Line: Vikings (-185); Browns (+155) Total: 36.5; Opened: 37.5 FPI favorite: Vikings by 5.5 with a 63.73% probability to win the game outright"
Week 5 of the NFL includes Thursday's NFC West matchup with the San Francisco 49ers visiting the Los Angeles Rams and Sunday night's divisional meeting between the Buffalo Bills and New England Patriots. The Kansas City Chiefs travel to face the Jacksonville Jaguars on Monday Night Football at 8:15 p.m. ET. Bye weeks begin for the Atlanta Falcons, Chicago Bears, Green Bay Packers and Pittsburgh Steelers. Odds and betting lines for every Week 5 game are listed, including point spreads, money lines, totals and opening numbers. FPI projections accompany each matchup, giving favorites with win probabilities.
Read at www.espn.com
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