ESPN BET has listed only one team, the Buffalo Bills, as favorites in every NFL regular-season game of 2025. This includes high-stakes matchups like their opener against the Ravens and a significant 12.5-point spread against the Saints in Week 4. Experts suggest the Bills' top position reflects their favorable schedule and strong odds, attracting substantial Super Bowl betting interest. In contrast, teams like the Saints and Browns struggle, especially following quarterback changes, indicating a more uneven season for certain franchises. Historical context shows fluctuating favorites and underdogs in the league over recent decades.
The Bills have attracted more bets to win the Super Bowl than any other team at ESPN BET following the release of the 2025 schedule.
Buffalo is favored by 12.5 points over the New Orleans Saints in Week 4, tied for the largest opening line on the board.
They have the ability to take advantage of their simpler schedule and weaker division.
The Saints took a significant drop in ratings after Derek Carr announced his retirement.
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