No, particle physics colliders cannot ever destroy the Universe

"Many of the mysteries of how our Universe began and evolved from the earliest times can be best investigated by this exact method: colliding particles at higher and higher energies. New particles and rare processes can be revealed through accelerator physics at or beyond the current energy frontiers, but this is not without risk."

"If we can reach energies that reveal/demonstrate the ability to create more matter than antimatter (or vice versa), restore the inflationary state that preceded and set up our hot Big Bang, or push the Universe's zero-point energy out of its "false minimum" state and into another state, certain consequences - some of which may be catastrophic - could be in store for us all."

"And yet, just as we knew that a common fear from 2008, that "the LHC could create black holes that destroy the Earth," was unfounded, we also know that any particle physics experiment we perform on Earth won't give rise to any of those dire consequences that we can dream up at all. The Universe, as well as Earth, remains safe from any current or planned particle accelerators."

Exploring deeper into the unknown through particle physics research presents both opportunities and concerns. Advancing into higher-energy frontiers enables investigation of early Universe processes and discovery of new particles and rare phenomena. However, theoretical risks exist if experiments could create matter-antimatter imbalances, restore inflationary states, or alter zero-point energy. Despite public fears about catastrophic consequences from particle accelerators like the LHC, scientific understanding confirms that current and planned Earth-based experiments cannot produce such dire outcomes. The Universe and Earth remain safe from existing accelerator technology.

Read at Big Think