A 1951 publication on protein assay in the Journal of Biological Chemistry is the most cited scientific paper with over 350,000 citations. The top-100 list features numerous works on biological techniques, AI, and statistics. An update from 2014 shows half the papers have changed due to increasing citations—which now require over 30,000 to enter the top 100. Analysis from various databases corroborates the 1951 paper's dominance, although newer AI research is quickly gaining ground.
The most highly cited paper in scientific literature is a 1951 publication detailing an assay for measuring protein concentration, cited over 350,000 times.
Many of the top-cited papers focus on biological laboratory techniques, with new entries from AI and statistical methods gaining visibility over recent years.
The requirements to make the top-100 list in citations have significantly increased, reflecting the rapid changes in research impact and relevance.
An analysis across various databases shows that despite variances, many rankings highlight the enduring significance of seminal research from the mid-20th century.
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