The addendum discusses findings on weight loss associated with cysteine deficiency, emphasizing a study that reports significant weight loss in Cse knockout mice due to cysteine restriction. Notably, both studies observe important biochemical and physiological responses, including increased lipid utilization and thermogenesis mediated by FGF21. The enhancements in our understanding of cysteine's role in these processes are presented in context with mechanistic insights provided by detailed examination of adipose tissue changes and signaling pathways, thereby strengthening the existing literature on metabolic health and nutrition.
Our findings complement Lee et al.'s work by confirming that cysteine depletion leads to significant adipose tissue changes and thermogenesis; providing insight into weight loss mechanisms.
Cysteine restriction triggers substantial weight loss in models, prompting metabolic shifts that enhance lipid utilization and energy expenditure, showcasing the complexity of nutrient deficiencies.
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