San Francisco experienced a sharp increase in overdose deaths in 2025, reversing a decline noted in 2024. The previous year had seen the lowest overdose rates in five years, leading to optimism regarding the city’s fentanyl crisis. However, experts indicate this decline may have been a temporary result of supply chain disruptions affecting potent fentanyl availability. By May 2025, overdose deaths had already risen, predicting a total of 746 for the year, closer to the record high in 2023.
The sharp decline in San Francisco overdose deaths in 2024 appears to be reversing itself in 2025, with new synthetic opioids fueling a potential deadlier year.
In 2024, San Francisco saw the lowest overdose death rate in five years, but experts suggest this may have been a temporary mirage due to supply disruptions.
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