"A single DNA tweak in a non-coding region of the X chromosome called enhancer 13 (En13) can trigger 'sex reversal' in female mouse embryos. Researchers found that a modification to En13 caused female mice to develop male genitals and small testes, but En13 had to be altered on both copies of the X chromosome for the change to occur."
"A set of genetic variants could help to explain why obesity drugs are more effective or cause more severe side effects in some people than others. Researchers found that people carrying one or two copies of a specific variant in the gene encoding the receptor for glucagon-like peptide-1 (GLP-1) lost more weight during treatment than those with none."
Partial reprogramming, which resets a cell's biological clock, is expected to enter clinical trials later this year. A single DNA modification in the enhancer 13 region of the X chromosome can cause female mice to develop male reproductive organs. Additionally, genetic variants may explain the varying effectiveness of obesity drugs among individuals, with certain variants linked to greater weight loss during treatment. These findings highlight significant advancements in genetic research and potential clinical applications.
Read at Nature
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