Editorial Expression of Concern: Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

"Addendum to: Nature https://doi.org/10.1038/nature04217 Published 13 October 2005 The Editors are issuing an Editorial Expression of Concern to alert readers that after the publication of this article, it was brought to the attention of the Editors that Fig. 2b and 2c appear to overlap with frameshift. Upon reviewing their article, the authors also found an additional overlap between the two DMSO panels of Fig. 2c. Due to the age of the article not all of the raw data are available for verification."

"Expression of Concern to alert readers that after the publication of this article, it was brought to the attention of the Editors that Fig. 2b and 2c appear to overlap with frameshift. Upon reviewing their article, the authors also found an additional overlap between the two DMSO panels of Fig. 2c. Due to the age of the article not all of the raw data are available for verification. Readers are urged to take caution when interpreting the content and conclusions of this article."

Figure 2b and 2c contain apparent overlapping frames, including a frameshift that suggests duplication or misalignment of image data and raises concerns about image integrity. An additional overlap exists between the two DMSO panels of Figure 2c, indicating possible reuse of control images. Not all original raw data remain available for independent verification because of the age of the materials and data retention limits. These issues introduce uncertainty about the integrity and reliability of the reported findings, particularly those relying on the affected figures. Readers are urged to exercise caution when interpreting the content and conclusions.

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