"EpsteinBarr virus (EBV) infects 90-95% of the global population1,2 and persists in B cells as a life-long infection3. Prior EBV-infection is associated with autoimmune and neoplastic disease4. Still, the biological basis of host control during EBV persistence remains unclear. Here, we report the identification of non-genetic and genetic factors that are associated with EBV control during persistent infection. Using blood-based genome sequence (GS) data from 486,315"
"UK Biobank and 336,123 All of Us participants, we identified short read-pairs mapping to the EBV genome in 16.2% and 21.8% of individuals, respectively. EBV-read detection (EBVread+) reflects increased viral load in blood cells, as shown by orthogonal measurements, and was associated with HIV infection, immunosuppressive drug intake, and current smoking. Genome-wide analyses of EBVread+ identified strong associations at the Major Histocompatibility Complex (MHC), including 54 independent HLA-alleles of"
Blood-based genome sequencing from 486,315 UK Biobank and 336,123 All of Us participants revealed short read-pairs mapping to the Epstein-Barr virus (EBV) genome in 16.2% and 21.8% of individuals, respectively. Detection of EBV reads (EBVread+) reflects increased viral load in blood cells as confirmed by orthogonal measurements. EBVread+ status is associated with HIV infection, intake of immunosuppressive drugs, and current smoking. Genome-wide analyses of EBVread+ show strong genetic associations at the Major Histocompatibility Complex (MHC), including numerous independent HLA alleles linked to control of EBV persistence.
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