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"Standard brain implants use electrodes that penetrate the gray matter to stimulate and record the activity of neurons. These typically need to be put in place via a surgical procedure. To go around that need, a team of researchers led by Deblina Sarkar, an electrical engineer and MIT assistant professor, developed microscopic electronic devices hybridized with living cells. Those cells can be injected into the circulatory system with a standard syringe and will travel the bloodstream before implanting themselves in target brain areas."

""In the first two years of working on this technology at MIT, we've got 35 grant proposals rejected in a row," Sarkar says. "Comments we got from the reviewers were that our idea was very impactful, but it was impossible." She acknowledges that the proposal sounded like something you can find in science fiction novels. But after more than six years of research, she and her colleagues have pulled it off."

"In 2022, when Sarkar and her colleagues gathered initial data and got some promising results with their cell-electronics hybrids, the team proposed the project for the National Institutes of Health Director's New Innovator Award. For the first time, after 35 rejections, it made it through peer review. "We got the highest impact score ever," Sarkar says. The reason for that score was that her technology solved three extremely difficult problems."

A team at MIT developed microscopic electronic devices hybridized with living cells that can be injected into the circulatory system and self-implant in target brain regions. The cell-electronics hybrids travel through the bloodstream after syringe injection and lodge near brain areas without requiring surgical implantation. The approach overcomes challenges including fabricating functional electronics smaller than cells, distinguishing electronics from passive magnetic particles, and enabling devices to function in vascular circulation. Initial experiments produced promising data, leading to high-impact peer review recognition and funding after multiple rejections. The devices open possibilities for less-invasive neural stimulation and recording.

Read at Ars Technica