#car-t-cell-therapy
#car-t-cell-therapy
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#immunotherapy #clinical-trials #autoimmune-diseases #solid-tumors #cancer-immunotherapy #cancer-treatment
Cancer
fromwww.theguardian.com
2 weeks agoThe emerging cancer treatment that's exciting scientists: We've just scratched the surface on what's possible'
CAR T-cell therapy reprograms immune cells to target cancer, with multiple approved options for blood cancers and ongoing efforts to expand to solid tumors.
fromNature
2 months agoIn vivo site-specific engineering to reprogram T cells - Nature
Using CRISPR-Cas9 and adeno-associated virus (AAV)-mediated homology-directed repair, we targeted CAR integration into the endogenous human TCR alpha locus (TRAC). TRAC-CAR T cells display dynamic CAR expression that delays exhaustion and improves tumour control in xenograft and immunocompetent models. This work has been critical for the development of allogeneic CAR T cell therapy, as it disrupts the TCR after transgene insertion—a necessary step to limit graft-versus-host disease.
Cancer
Medicine
fromNews Center
8 months agoCelebrating Scientific Discovery and Collaboration at Research Day 2025 - News Center
Feinberg's 19th annual Lewis Landsberg Research Day showcased over 470 research posters, honored faculty achievements, and highlighted mRNA and CAR T-cell advances against cardiac fibrosis.
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