#ferroptosis

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#t-cell-immunity #dietary-fatty-acids #immune-homeostasis #lipid-metabolism #oestradiol #acute-kidney-injury
fromwww.nature.com
1 week ago

Lipid metabolism drives dietary effects on T cell ferroptosis and immunity

Ferroptosis, a major mechanism of non-apoptotic programmed cell death, critically regulates the homeostasis and functionality of peripheral CD4+ and CD8+ T cells. Here we demonstrate that in mouse, resistance of T cells to ferroptosis depends critically on the composition of standard rodent diets, and that dietary effects on ferroptosis have a crucial role in regulation of T cell homeostasis and immune responses.
Medicine
fromwww.nature.com
1 month ago

Publisher Correction: Multiple oestradiol functions inhibit ferroptosis and acute kidney injury

Publisher Correction: Multiple oestradiol functions inhibit ferroptosis and acute kidney injury Publisher Correction Open access Published: 21 January 2026 Wulf Tonnus orcid.org/0000-0002-9728-14131 na1, Francesca Maremonti2 na1, Shubhangi Gavali orcid.org/0000-0003-2876-14532 na1, Marlena Nastassja Schlecht orcid.org/0000-0001-8893-53261, Florian Gembardt2, Alexia Belavgeni orcid.org/0000-0001-6311-58583, Nadja Leinung2, Karolin Flade orcid.org/0009-0009-5449-28251, Natalie Bethe1,
Science
fromNature
4 months ago

Targeting FSP1 triggers ferroptosis in lung cancer - Nature

Ferroptosis is oxidative, lipid-peroxidation-driven cell death controlled by GPX4 and FSP1, with significant implications for cancer sensitivity and therapeutic targeting.
Cancer
fromNews Center
9 months ago

Targeting Tumor Metabolism to Trigger Cancer Cell Death - News Center

Researchers found a method to exploit treatment-resistant cancer cells' metabolic vulnerabilities leading to cell death through ferroptosis.
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