UM171 glues asymmetric CRL3-HDAC1/2 assembly to degrade CoREST corepressors - NatureGlue degraders induce protein degradation and differ from PROTACs in that they do not binding to one of the protein partners.Slow development of glue degraders stems from poor understanding of their functional needs and E3 scaffold preferences.
Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity - NatureAge-related changes in hematopoietic stem cells (HSCs) contribute to immune system aging.Antibody-mediated depletion of myeloid-biased HSCs in aged mice can reverse features of immune aging.