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#genetics
Health
fromThe Washington Post
1 week ago

One way to live longer: Win the genetic lottery

Genetic factors account for about 50% of human lifespan, significantly higher than the previously estimated 20%.
fromNature
2 weeks ago

Can a mouse be cloned indefinitely? Decades-long experiment has answers

Asexual reproduction is ultimately unsustainable for mice, and potentially other mammals, too. The clones looked normal and lived as long as normal mice. But large mutations - including the loss of an entire chromosome - accumulated in the cloned lineage at an unusually high rate.
OMG science
Cancer
fromThe Washington Post
3 weeks ago

J. Michael Bishop, who illuminated genetic roots of cancer, dies at 90

J. Michael Bishop, Nobel Prize-winning microbiologist, died at 90 from pneumonia, known for his groundbreaking cancer research and leadership at UCSF.
Science
fromNature
1 month ago

Daily briefing: How DNA testing can tell identical twins apart

Advanced forensic techniques including whole-genome sequencing and epigenetic analysis can differentiate between identical twins in criminal investigations, while GLP-1 drugs show potential in reducing addiction across multiple substances, and researchers have successfully synthesized hexagonal diamond.
Science
fromArs Technica
1 month ago

Large genome model: Open source AI trained on trillions of bases

Evo 2, an AI system trained on trillions of base pairs from all life domains, can identify genes, regulatory sequences, and splice sites in complex genomes including humans.
fromwww.nature.com
1 month ago

BCDX2CX3 and DX2CX3 complexes assemble and stabilize RAD51 filaments

Central to HR is the RAD51 recombinase, whose assembly into a nucleoprotein filament is governed by five RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, XRCC3). Mutations in any of these proteins predispose individuals to multiple cancers or genetic disorders. These paralogs are thought to form two functionally separate complexes, BCDX2 and CX3, that act independently at different stages of HR.
OMG science
fromNature
1 month ago

Daily briefing: This Utah family line might be evidence of 'selfish genes' in humans

Researchers identified a Utah family with seven generations showing twice as many boys as girls, providing first clear evidence of sex-ratio distorting genes in humans.
fromNews Center
2 months ago

AI Model May Improve RNA Sequencing Research - News Center

Scientists in the laboratory of Rendong Yang, PhD, associate professor of Urology, have developed a new large language model that can interpret transcriptomic data in cancer cell lines more accurately than conventional approaches, as detailed in a recent study published in Nature Communications. Long-read RNA sequencing technologies have transformed transcriptomics research by detecting complex RNA splicing and gene fusion events that have often been missed by conventional short-read RNA-sequencing methods.
Cancer
Science
fromNature
2 months ago

Construction of complex and diverse DNA sequences using DNA three-way junctions - Nature

DNA writing remains limited by short oligo synthesis and two-way junction assembly methods, hindering affordable, scalable construction of large, complex synthetic DNA.
fromwww.bbc.com
2 months ago

AI model from Google's DeepMind reads recipe for life in DNA

Called AlphaGenome, the model could help scientists discover why subtle differences in our DNA put us at risk of conditions such as high blood pressure, dementia and obesity. It could also dramatically accelerate our understanding of genetic diseases and cancer. The developers of the model acknowledge it's not perfect, but experts have described it as "an incredible feat" and "a major milestone".
Science
fromFuturism
2 months ago

Jeffrey Epstein Had a Bizarre Obsession With "Improving" Human DNA, and He Was Emailing With Top Scientists About It

The newly released documents from the Justice Department shine additional light on how the convicted child sex criminal exhibited a fascination with transhumanism, a controversial movement in science and philosophy with a eugenicist mission: using cutting edge technology, including genetic engineering and AI, to advance the biology of the human race. They also reinforce how serious Epstein was about pursuing these ideas.
Science
Science
fromHarvard Gazette
2 months ago

Memorial Minute for Nikolaas Johannes Van Der Merwe, 85 - Harvard Gazette

Nikolaas J. van der Merwe pioneered carbon and nitrogen isotope analysis, transforming dietary reconstruction and advancing archaeology, radiocarbon techniques, and related sciences.
Science
fromwww.scientificamerican.com
2 months ago

How long you live may depend much more on your genes than scientists thought

Heritability of human lifespan roughly doubles to about 50% when extrinsic mortality is removed, showing a stronger genetic influence on intrinsic aging.
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