Medicine
fromwww.scientificamerican.com
1 week agoHow well GLP-1 weight loss drugs work may depend on your genetics
Genetic variations can explain why some individuals do not respond to weight-loss drugs like Wegovy and Zepbound.
In the originally published version of this article, Extended Data Fig. 4 contained inadvertent duplications introduced during figure assembly: panel 4c (the bottom of the second column) erroneously reused images from panel 4a (the bottom of the third column); panel 4c (the upper panel of the third column) erroneously reused images from panel 4a (the upper panel of the rightmost column);
Ferroptosis, a major mechanism of non-apoptotic programmed cell death, critically regulates the homeostasis and functionality of peripheral CD4+ and CD8+ T cells. Here we demonstrate that in mouse, resistance of T cells to ferroptosis depends critically on the composition of standard rodent diets, and that dietary effects on ferroptosis have a crucial role in regulation of T cell homeostasis and immune responses.