#peripheral-immune-tolerance
#peripheral-immune-tolerance
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#regulatory-t-cells #autoimmunity #nobel-prize-2025 #foxp3 #immunology #autoimmune-disease #2025-nobel-prize
#regulatory-t-cells
fromThe Mercury News
1 week agoMedicine
San Francisco scientist shares Nobel Prize in medicine with 2 others for work on the human immune system
Discovery of regulatory T cells and the Foxp3 gene revealed peripheral immune tolerance mechanisms that prevent autoimmune disease and enable new immunotherapies.
fromSFGATE
1 week agoSF scientist, UC alum nabs Nobel Prize for immune system discoveries
In 2001, Ramsdell and Brunkow made a key discovery while studying a mouse strain prone to autoimmune disease. Together, the researchers found that mice possessed a mutation of a gene they named "Foxp3," which they compared to the mutations in the human version of the same gene, which caused a severe autoimmune disorder known as IPEX. Two years later, Sakaguchi demonstrated that Foxp3 played a key role in producing a class of immune cells he had first identified in 1995.
Medicine
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