In order to make it onto our list, we started by looking for spots that were highly-rated and widely recommended by customers, but there are a lot of those places to be honest. Consequently, we also looked for places that get seriously creative with its pies while still offering all the old-school tradition - like a delicious crust appropriate to the style in question - that people have come to expect.
According to 50 Top Pizza, America's second-best pizzeria is Pizzeria Sei - the same pizzeria that tops Tasting Table's ranking of the 20 absolute best pizza places in Los Angeles. Pizzeria Sei prides itself on its intimate atmosphere and concise menu. It only offers eight different, Neapolitan-style pizzas. Not only is it recognized as one of the best in the U.S., but 50 Top Pizza also crowned it as the ninth-best pizzeria in the world in 2025.
New York's passion for pizza may only be rivaled by Italy's, so it's no small feat when Italian judges rank an Upstate shop among the best on the planet. Jay's Artisan Pizzeria in Kenmore, just north of Buffalo, has landed on the Guide to the 50 Best Pizzerias in the World for the fourth straight year. This year, Jay's broke into the top 15, earning the No. 14 spot. The annual list, published in Italy by 50 Top Pizza, features heavyweights from pizza capitals such as Naples, Barcelona, Rome and New York City.