#protein-engineering

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#molecular-glues #artificial-intelligence-drug-discovery #biotechnology-funding #computational-drug-design
Medicine
fromBusiness Matters
15 hours ago

UK biotech Ternary raises 3.6m to scale AI platform for next-generation drugs

Ternary Therapeutics secured £3.6 million in seed funding to develop an AI-driven platform for engineering molecular glues, a new class of medicines that bring proteins together to destroy disease-causing targets.
Science
fromThe Washington Post
5 months ago

How AI is making it easier to design new toxins without being detected

AI-designed proteins can bypass current biosecurity screening, requiring ongoing patches, adversarial testing, and continuous monitoring to prevent misuse.
fromNature
5 months ago

Design of facilitated dissociation enables timing of cytokine signalling - Nature

Protein-protein interactions orchestrate much of biological function. High-affinity interactions enable protein circuits to respond to low concentrations of stimuli and to act potently on targets; fast exchange enables them to respond quickly to changes in stimuli. These two properties cannot usually be achieved simultaneously in binary interactions because they depend on the interaction off-rate in opposite ways: high affinity usually requires slow dissociation (low off-rate), whereas rapid exchange requires fast dissociation (high off-rate) (Supplementary Fig. 1).
Science
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