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1 week agoSperm sequencing reveals extensive positive selection in the male germline - Nature
All human cells accumulate mutations throughout life. In proliferating tissues, acquired driver mutations that confer a selective advantage can promote the expansion of individual clones in competing stem and progenitor cell populations. Although patterns of selection and clonal expansion have been extensively studied in cancers, recent research has also highlighted their occurrence in normal tissues during ageing6,7,8,9,10,11,12,13,14. Spermatogonial stem cells of the testis occupy a distinct niche relative to other studied normal tissues.
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