#t-cell-exhaustion

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#transcription-factors #immunology #viral-infection #cancer-therapy #cd4-t-cells #th1-differentiation
Cancer
fromNews Center
1 week ago

Transcription Factors Form Continuous 'Circuit' That Regulates T-cell Exhaustion - News Center

Two transcription factors regulate T-cell exhaustion and migration, impacting therapeutic strategies for infections and cancer.
fromNews Center
1 month ago

Targeting Cellular Mechanisms May Improve Immune Response in Chronic Infections - News Center

During viral infection and in the case of cancer, CD4+ helper T-cells release cytokines, or small signaling proteins, that activate and "give permission" to other immune cells to control and clear viral pathogens. In certain viral infections, such as lymphocytic choriomeningitis virus (LCMV), which is spread by infected rodents, CD4+ T-cells differentiate into different subpopulations, including one subset of progenitor CD4+ T-cells that replenish type 1 helper (Th1) and follicular helper (Tfh) T-cells.
Science
Medicine
fromNature
2 months ago

Atlas-guided discovery of transcription factors for T cell programming - Nature

Transcription factors determine CD8+ T cell states; identifying TFs that promote tissue-resident memory versus terminal exhaustion enables engineering of more effective adoptive T cell therapies.
Medicine
fromNature
6 months ago

Proteotoxic stress response drives T cell exhaustion and immune evasion - Nature

Proteomic profiling of exhausted T cells reveals pathway-specific transcript–protein discordance and identifies T cell–exhaustion-specific protein-level regulatory mechanisms.
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