A recent study published in the Annals of Internal Medicine found that individuals vaccinated with COVID-19 boosters in 2023-2024 had a higher likelihood of contracting COVID-19 compared to those who were unvaccinated. The study, utilizing data from the U.S. Veterans Health Administration, revealed a vaccine efficacy of -3.26%, pointing to a significant increase in infection rates among the vaccinated. Additionally, efficacy against hospitalization and death was noted to wane quickly, prompting calls for new vaccination strategies to enhance protection as natural immunity levels rise in the population.
People vaccinated with the COVID-19 boosters in 2023-2024 were more likely to get COVID-19 than their unvaccinated counterparts.
Vaccine efficacy against COVID-19 infection was -3.26%, indicating a statistically significant higher infection rate in vaccinated individuals compared to the unvaccinated control group.
Our findings call for accelerated efforts to develop new vaccination strategies that could provide higher and more sustained protection in the current era of COVID-19.
It was, therefore, uncertain how much additional protection the vaccine would provide in a population which by then had substantial levels of natural immunity.
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