Researchers at the University of Toronto have identified furanodienone (FDN), a compound in ginger, as a potential treatment for inflammatory bowel disease (IBD). The study revealed that FDN selectively binds to the pregnane X receptor (PXR), which plays a significant role in reducing inflammation by suppressing pro-inflammatory cytokines. This discovery emphasizes the potential of natural products in developing cost-effective therapies for IBD, particularly as current treatments are often life-long and do not cure the disease. The findings pave the way for further investigation into ginger-derived compounds and their effects on IBD.
We found that we could reduce inflammation in the colons of mice through oral injections of FDN, highlighting the potential of complementary medicine for IBD.
Our discovery of FDN's target nuclear receptor highlights how natural products might regulate nuclear receptors more precisely than synthetic compounds.
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