Recent research published in PNAS reveals that cannabinoids such as CBD, CBG, and CBN inhibit the Nav1.8 sodium channel, a key player in pain transmission. This study highlights CBG as the most potent of the three, showing significant potential for natural pain relief. By reducing sensory nerve excitability and interrupting pain signals, these cannabinoids could decrease the need for opioids in pain management. The FDA's approval of suzetrigine, a drug that also blocks Nav1.8, further validates the analgesic potential of these compounds for pain treatment.
Of the three cannabinoids studied, CBG showed the greatest promise, demonstrating strong pain-blocking potential through its ability to inhibit Nav1.8 more effectively than CBD or CBN.
This study confirms that cannabinoids like CBD, CBG, and CBN inhibit the Nav1.8 sodium channel, effectively acting as natural painkillers and reducing reliance on opioids.
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