Recent studies have uncovered a connection between non-viral chronic liver disease (CLD) and the onset of liver cancer, particularly hepatocellular carcinoma (HCC). Research conducted by Hiroshima University focused on how inflammation and aging contribute to HCC development. By analyzing gene expression and metabolites from non-cancerous liver tissue adjacent to HCC lesions, the team aimed to illuminate the molecular mechanisms leading to cancer. Their findings highlight potential pathways for chemoprevention, including the beneficial effects of substances like green tea.
In this study, we analyzed non-cancerous liver tissue adjacent to HCC lesions from patients with non-viral chronic liver disease. Through multi-omics analysis of transcriptomic and metabolomic data, we aimed to uncover molecular mechanisms underlying HCC development and identify novel targets for chemoprevention.
Liver cancer can arise spontaneously from healthy liver tissue. Recently, however, researchers have discovered an increasing correlation between some liver cancers and non-viral chronic liver disease (CLD).
The increasing prevalence of CLD with HCC suggests that this underlying condition predisposes liver tissue to cancer development.
While increasing awareness and screening of cancers has improved the ability to detect liver cancer at earlier stages when it is more effectively treated, cancer prevention is always a primary goal of both healthcare providers and biomedical researchers.
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