Nonalcoholic fatty liver disease (NAFLD) is increasingly common yet often unnoticed until it causes serious harm. Research indicates that nutrient depletion, especially vitamin D deficiency, is a significant factor in NAFLD development, not just affecting the unhealthy or overweight. Vitamin D plays critical roles in fat metabolism, inflammation regulation, and energy production in liver cells. Recent studies show that vitamin D3 supplementation can reduce liver fat, normalize liver weight, and lower inflammation, highlighting its importance in liver health and disease management.
Older animals with low vitamin D had more fat in the liver - The study looked at 22-month-old mice, roughly the equivalent of humans in their 70s, compared with younger adult mice. Older mice with lower vitamin D levels had much higher fat accumulation in their livers, while those given high-dose vitamin D3 (20,000 IU/kg) saw marked improvement. Liver fat decreased, liver weight normalized and inflammation dropped significantly.
Vitamin D doesn't just support liver function; it controls it at the genetic level. This discovery has major implications for how to prevent, manage and even reverse liver disease tied to aging and metabolic stress.
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