Alex Cora made a series of lineup changes coming off Tuesday's extra-innings win, which put Boston in position to earn a series sweep.
The pitching matchup will feature a pair of right-handers coming off season-opening losses, though they experienced very different results in their respective 2024 debuts.
Nick Pivetta struck out 10 Mariners over six innings of one-run ball in Seattle last week.
Ross Stripling, meanwhile, was tagged for five runs (four earned) on seven hits over five frames against the Cleveland Guardians.
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