Scientists at Northwestern Medicine have found that inhibiting the GATA6 protein in mouse models of colon cancer can significantly reduce tumor growth and improve survival rates. This groundbreaking study, published in Science Advances, identifies GATA6 as a crucial regulator of oncogenes in colon cancer. Previous studies highlighted GATA6’s role in tumor growth, but its exact function in gene regulation was unclear. The research team conducted genomic profiling and RNA sequencing, discovering that GATA6 interacts with specific active enhancers and the tumor-suppressor protein CTCF, providing new insights into colon cancer progression.
This is the first time we show that GATA6 is a global regulator and controls many key oncogenes in colon cancer.
Traditionally, there has been very little known about what transcription factors are involved with the tissue-specific genome folding. So, this is actually one of the few cases that we show that an important transcription factor is directly responsible for the DNA folding in this disease-specific pattern.
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