The recent study unveils the structure of the poxvirus core protease (CorePro), a crucial component in viral maturation and a key target for antiviral drug development. Particularly, the structures of the mpox virus (MPXV) CorePro in both its apo form and when bound to an inhibitor, aloxistatin, were elucidated. This advancement addresses a significant gap in understanding poxvirus biology and offers a framework for developing focused antiviral therapies against smallpox and mpox, which pose serious health threats globally.
The structure of CorePro from poxviruses, crucial for viral maturation, has been determined, providing a target for potential antiviral drug development.
Understanding the structure of poxvirus CorePro revealed critical insights, paving the way for developing specific inhibitors to combat severe poxvirus diseases.
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