Substrate recognition and cleavage mechanism of the monkeypox protease, Core protease
The structure of CorePro from poxviruses, crucial for viral maturation, has been determined, providing a target for potential antiviral drug development.
Microsoft Releases BioEmu-1: A Deep Learning Model for Protein Structure Prediction
BioEmu-1 revolutionizes protein structure prediction by generating ensembles rather than static models, enhancing understanding in drug development and biology.
Structural dynamics of human fatty acid synthase in the condensing cycle
In our study on human FASN, we reveal that its function does not require large rotational motion, highlighting the unsynchronized nature of catalytic reactions during fatty acid synthesis.