Increased PGE2 production from aberrant COX1 and COX2 activity is observed in tumors, impacting cancer progression and patient survival. PGE2 signaling through EP2/EP4 receptors influences immune cell function, including T cell responses in anticancer immunity.
Deleting EP4 in CD4+ and CD8+ T cells in mice showed improved tumor immune control. EP2/EP4 axis manipulations can affect tumor escape from anticancer T cell responses, offering insight into potential therapeutic targets.
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