In naive individuals, sensory neurons detect allergens, causing itch and activating innate immune cells to initiate the allergic immune response, but mechanisms are poorly understood.
We define a poorly characterized γδ T cell subset, GD3 cells, that produces IL-3, promoting allergic itch and initiating the allergic immune response through specific mechanisms.
The IL-3 acts on sensory neurons in a JAK2-dependent manner, lowering the threshold for allergen activation, but does not independently cause itch, highlighting complex interactions.
This γδ T cell-IL-3 signaling axis may explain variations in allergic susceptibility among individuals and suggests new therapeutic approaches for allergic diseases.
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