"There's plenty of encouraging news for people taking GLP-1 drugs like Ozempic to lose weight and reduce the risk of diabetes: countless people who have lost weight while using it and seen other health benefits as a result. But along with the good news come some bleaker aspects, with some people taking these drugs and reporting feelings of nausea as a result."
"NPR details a number of presentations made at Neuroscience 2025, the annual meeting of the Society for Neuroscience, in which different experts proposed an array of solutions to GLP-1 drugs' nausea problems.One of the more intriguing proposals came from University of Washington researcher Ernie Blevins. Hamilton describes the method that Blevins and his colleagues used on rats: giving them GLP-1 drugs to reduce their appetite, and then giving them small doses of oxytocin, a hormone that can be used to reduce nausea."
GLP-1 drugs such as Ozempic produce substantial weight loss and lower diabetes risk but can cause nausea in some patients. Neurologists and researchers are testing strategies to mitigate these stomach-related side effects, including animal studies combining GLP-1 drugs with small doses of oxytocin to reduce nausea. Separate efforts are advancing oral GLP-1 agents like orforglipron, which demonstrated superior results to placebo across multinational trials. An effective oral GLP-1 could simplify dosing, increase access, and improve health outcomes for people with obesity and diabetes while researchers continue refining the class to balance efficacy and tolerability.
Read at InsideHook
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