The article discusses a novel technique named Trace-n-seq, developed to map neurons associated with pancreatic ductal adenocarcinoma (PDAC). Pancreatic cancers are heavily infiltrated by peripheral nervous system (PNS) neurons, which complicate the tumor microenvironment. However, direct access to neuronal cell bodies, located in various ganglia, makes studying these interactions difficult with traditional sequencing methods. Trace-n-seq allows researchers to trace axons from tissues, isolating and characterizing PNS neurons at a single-cell transcriptomic level, offering new opportunities to understand their influence on tumor development and progression.
The peripheral nervous system (PNS) orchestrates organ function in health and disease, impacting pancreatic cancer through its complex interaction with the tumor microenvironment.
Our novel Trace-n-seq technique allows for the characterization of PDAC-innervating neurons, providing insights into their role in tumor development.
#pancreatic-cancer #peripheral-nervous-system #preclinical-research #neuroscience #tumor-microenvironment
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