"When a person suffers a stroke, physicians must restore blood flow to the brain as quickly as possible to save their life. But, ironically, that life-saving rush of blood can also trigger a second wave of damage - killing brain cells, fueling inflammation and increasing the odds of long-term disability. Now, in a study published in the journal Neurotherapeutics, Northwestern University scientists have developed an injectable regenerative nanomaterial that helps protect the brain during this vulnerable window."
"In a new preclinical study, the team delivered a single intravenous dose, immediately after restoring blood flow, in a mouse model of ischemic stroke, the most common type of stroke. The therapy successfully crossed the blood-brain barrier - a major challenge for most drugs - to reach and repair brain tissue. The material significantly reduced brain damage and showed no signs of side effects or organ toxicity."
An injectable regenerative nanomaterial based on supramolecular therapeutic peptides (STPs) targets secondary injury after ischemic stroke. A single intravenous dose given immediately after blood flow restoration in a mouse model reached the brain by crossing the blood-brain barrier and promoted tissue repair. The material significantly reduced brain damage and inflammation and showed no signs of side effects or organ toxicity in preclinical testing. Current clinical approaches remain focused on restoring blood flow, leaving an unmet need for therapies that facilitate neuronal recovery. The nanomaterial could complement reperfusion treatments by limiting secondary injury and supporting recovery.
Read at News Center
Unable to calculate read time
Collection
[
|
...
]