Breakthrough as 40-year-old drug is revamped to destroy cancer cells
Patented mebendazole polymorph C reaches tumors, including brain tumors, at higher concentrations and shows stronger anticancer effects, especially when combined with efflux inhibitors.
"Supercharged" vitamin K derivatives offer new hope for neurodegenerative diseases
Synthetic vitamin K analogues, especially compound 7, strongly activate mGluR1 signaling and more potently induce neural progenitor differentiation, showing promise for neuron regeneration therapies.
Repeated head trauma causes neuron loss and inflammation in young athletes - Nature
Repetitive head impacts produce early neuroinflammation, blood-brain barrier breakdown, astrocytic and white matter pathology that precede p-tau deposition and drive early CTE.
A leaky blood-brain barrier can cause psychiatric illness; boosting mitochondrial function in barrier cells repairs the barrier and relieves impaired social interaction.