The 49ers are banged up, but starting quarterback Brock Purdy is expected to play after recovering from a shoulder injury and fully participating in Friday's practice.
Head coach Kyle Shanahan confirmed Brock Purdy's availability for the Bills game, noting he showed no setbacks after a full practice participation the day before.
Josh Dobbs, serving as a backup for Purdy, may suggest potential changes to the 49ers' run game strategy, indicating a shift towards utilizing a more mobile quarterback.
Despite losing key players like Nick Bosa and Trent Williams, the 49ers are still fielding active players who were questionable earlier in the week, enhancing their depth.
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