The X chromosome presents a unique challenge in human genetics, necessitating that females inactivate one of their two X chromosomes for gene dosage balance. Jeannie Lee's lab has contributed significantly to our understanding of this process. Their recent study reveals that this inactivation occurs through a gelatinous substance that coats chromosomes, which allows the RNA molecule Xist to modify its properties, thereby facilitating the silencing of the X chromosome. Understanding this process offers potential therapeutic avenues for diseases linked to mutations on the X chromosome.
Inactivation of one X chromosome in females is mediated by a gelatinous substance surrounding chromosomes, which facilitates the action of Xist and other silencing molecules.
Jeannie Lee explains that the RNA molecule Xist engages in a tug-of-war with the gelatinous substance, eventually leading to X-inactivation.
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