"There are really very interesting things to be found out about circular RNAs," says Nikolaus Rajewsky, a systems biologist at the Max Delbrück Center for Molecular Medicine in Berlin. "Largely, it's terra incognita, and that's very exciting." This highlights the ongoing exploration of circRNAs and their potential functions that remain largely unknown, suggesting a deeper mystery that could lead to significant scientific breakthroughs.
Recent findings demonstrate that circular RNAs (circRNAs) are prevalent across the tree of life, rather than being mere artefacts of splicing. Their involvement in critical conditions like cancer, cardiovascular diseases, and Alzheimer’s disease opens fascinating avenues for therapeutic development and biomarker discovery. Understanding their role is vital in expanding our knowledge of RNA's function.
CircRNAs, by binding to microRNAs, prevent the latter from inhibiting messenger RNAs, thereby supporting protein production. This understanding illustrates the regulatory capability of these RNAs, positioning them as significant players in cellular processes and the intricate machinery of gene expression.
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