The article discusses how transcription processes can lead to DNA damage, which can contribute to mutations associated with cancer and neurodegenerative diseases. The authors identify a previously unknown source of damage occurring at termination sites of transcripts, capturing novel intermediates of DNA damage. Their research reveals that damage occurs in both bacterial and human cells and is linked to DNA replication dynamics. These findings highlight the frequent and critical nature of transcription-related DNA damage, challenging previous perceptions about DNA integrity during transcription.
In our study, we identified a new source of DNA damage that occurs at sites where transcription terminates, revealing an unexpected interaction between RNA and DNA processes.
Our findings indicate that DNA damage during transcription can occur more frequently than previously understood, emphasizing the need for further investigation into the mechanisms involved.
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